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Topiramate is an anticonvulsant medication used in the treatment of epilepsy and migraine headaches. Topiramate is also commonly used off-label to treat a wide range of mood disorders, eating disorders, and to aid in substance abuse therapy. While Topiramate's mechanism of action is unclear, we know that the drug blocks sodium channels in the body that deliver electrical impulses to excitable cells (such as nerve, muscle, and brain cells). By doing so, Topiramate appears to enhance the activity of a chemical messenger (neurotransmitter) known as gamma-aminobutyric acid (GABA).

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topiramate is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain). Topiramate is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topiramate is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur. Topiramate is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

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Serum cytokine and chemokine profiles in patients with juvenile muscular atrophy of distal upper extremity (Hirayama disease). This study suggests that topical analgesics may reduce the nociceptive input from inflamed muscles via a reflex mechanism by activating the cutaneous nociceptive afferents. Although in Msh2-deficient organoids MSI continuously increased from birth, growth characteristics remained stable at first. AWS seem to adopt a more restrictive, less flexible speaking approach in response to social-cognitive stress, which is presumably a strategy for maintaining observably fluent speech.

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Surgical management of isthmic spondylolisthesis with radicular pain. On the other hand, a higher radiation sensitivity of white rats in comparison with that of black rats is caused by low content of serotonin, thiols, melanin and other biologically active substances which are endogenous radioprotectors defining individual radioresistance. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. Among the reactions that form the double bond during the cyclization, the classical Horner-Emmons coupling is still frequently used with success.

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To evaluate the shear bond strength and bonding ability between the new nano-hydroxyapatite composite resin and tooth structure. Neurotensin (NT) has multiple functions, ranging from acting as a neurotransmitter to regulating intestinal movement. The so-called paradoxical extension of pre- and post-operative therapy following injuries of the finger extensor tendons Subsequently, a new case of CLL was confirmed with appropriate testing. In the present study, the role of the phosphatidylinositol 3 kinase (PI3K)-Akt pathway in regulating P.

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Growth of, and aflatoxin production by Aspergillus parasiticus when in the presence of either Lactococcus lactis or lactic acid and at different initial pH values. This is the first randomized, controlled study to assess the impact of VG genre on the development of basic surgical skills.

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However, injections of beta-EP1-27(O) or beta-EP1-26(H) failed to influence this response or to reverse the depressor action of levorphanol. The present study found no evidence among a cross-section of reinforced-plastics industry workers that current or historical exposure to styrene was associated with impairment of olfactory function. Binding site preorganization and ligand discrimination in the purine riboswitch.

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Paroxysmal hemoglobinuria with cold autoantibodies in a case of lymphosarcoma Besides the classical role of vitamin D on calcium and bone homeostasis, vitamin D deficiency has recently been identified as a contributing factor in the onset of insulin resistance in type 2 diabetes mellitus. Benefit to quality of life after off-pump versus on-pump coronary bypass surgery. In foreseeably permanent dysphagia, as well as permanent and necessary tracheotomy tube cuffs after organ-preserving surgery, alternative therapy methods should be particularly preferred as the primary chemoradiation.

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Recently, enhanced signaling of the PD-1/CTLA4 pathway has emerged as a critical mechanism by which tumors can escape the anti-tumor immune response. The use of such catalytically inactivated enzymes, which still retain their RNA binding capacity, allows the identification of novel RNA substrates of RNase III. While no primary wrist joint afferent fibres were recorded in the dorsal columns, their presence was demonstrated by recording single units in the wrist joint nerve which were antidromically activated by microstimulation in the cuneate fasciculus.

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We found that specific staining for DNA as well as the use of monoclonal anti-DNA antibodies show a complete absence of DNA in the CB. This has significantly improved the outcomes of renal transplant, including reduction of acute rejection episodes, improvement of renal function and graft survival, and reduction of some of the adverse effects associated with cyclosporine. These results indicate that preoperative CgA may be a clinically useful prognostic marker for patients undergoing pancreatic neuroendocrine tumor resection. Furthermore, the in vitro synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) by Golgi membranes was inhibited quantitatively. Proteinuria decreased in four studies and remained stable in one study.

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PMA-induced shedding of IL-6R in TACE deficient mouse fibroblasts could be restored by stable transfection of a TACE cDNA. The 1,3-dipolar cycloaddition reaction of chiral carbohydrate-derived nitrone and olefin: towards long-chain sugars. The differential diagnosis, particularly in comparison with the closely related genera Liga and Amoebotaenia, is presented: Liga possesses an atrial bundle of setae and Amoebotaenia 1 row of well built hooks with a typical blade. Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1). In corneal recipients with herpes infection, acyclovir given for 1 year postoperatively prevents viral reactivation and improves graft outcome.

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This study demonstrates that Cox-2-derived prostaglandins exert cytoprotective effects in trophic factor withdrawal apoptosis and provides evidence that this is, at least in part, due to suppression of caspase-3 activity. These problems have been overcome with the newest magnetic resonance-guided high intensity focused ultrasound systems (MRgHIFU). This multicenter case-control study included 284 incident PSP cases of 350 cases and 284 age-, sex-, and race-matched controls primarily from the same geographical areas. In Vitro and In Vivo Anti-Allergic and Anti-Inflammatory Effects of eBV, a Newly Developed Derivative of Bee Venom, through Modulation of IRF3 Signaling Pathway in a Carrageenan-Induced Edema Model.

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Dabigatran is one of the three newer oral anticoagulants (OACs) recently approved in the United States for stroke prevention in non-valvular atrial fibrillation (NVAF) patients. Next, the effect of ionising radiation on the duration of the S-phase was determined by pulse labelling cells with BrdUrd before irradiation. UCNPs are also useful for multimodal in vivo imaging because simple variations in the composition of the lattice atoms and dopant ions integrated into the particles can be easily implemented, yielding various distinct biomedical activities relevant to magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET). Our results demonstrate that one of these drugs, Nelfinavir, significantly decreases LDLR and LDLR-related protein (LRP) mRNA and protein levels, resulting in the reduced functional activity of these two receptors. The rate of absorption depends on the microwave parameters and the electrical and geometric properties of the subject.

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To evaluate the value of adding sonoelastography to conventional US in patients with congenital muscular torticollis. The survival of normal bone marrow progenitors has been estimated by colony formation assay in methylcellulose cultures.

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We also examined 47 bipolar affective patients and 62 control subjects for an association. A retrospective analysis and comparison was conducted on the clinical data of 122 test-tube premature infants and 183 naturally conceived premature infants (control group), including maternal complications, birth conditions and early complications. persulcatus (the rate of infection was 1.25 per cent) gathered in the southeastern Komi within the southern margins of the middle taiga subarea.

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A single training session is not sufficient in itself, however, to achieve the goal of universal preschool vision screening in the primary care setting. Furthermore we can calculate the metabolic control parameters using symbolic values for the conventional kinetic parameters. Samples of blood and cerebrospinal fluid (CSF) were also analyzed at similar intervals.

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Screening for Acromegaly in Patients with Carpal Tunnel Syndrome: A Prospective Study (ACROCARP). Clinical studies to examine the benefits of glutamine-enriched nutrition in hospitalized patients are under way. Qualitative content analyses of the transcriptions of the interviews and focus groups revealed that participants identified tangible benefits of the process oriented approach.

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First, using an automated measurement system at an office visit during the SPRINT protocol, while the patient was seated alone after 5min of quiet rest, may likely have resulted in lower BP values than would normally be obtained with the routine BP measurement. PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China. Also, the relationship between temporal processing and Chinese character reading is strongly influenced by age. Nephrotoxicity is the major dose-limiting toxicity of cisplatin (CDDP).

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The bone marrow as a source of serum hemolysin to sheep red blood cells (SRBC) was studied in splenectomized mice. Alterations in the structure of glutathione diminished the catalytic efficiency in the reduction of the acrolein adduct, consistent with the presence of specific interactions between the amino acid residues of glutathione and the AR active site. Defining the interactions between virus and cell proteins should provide a better understanding of how viruses propagate and cause disease. Recombinant His-tagged feline oviductin was expressed by transformed Escherichia coli BL21DE3 cells. Natural killer cell activity in patients with hepatocellular carcinoma relative to early development and tumor invasion.

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Mice had either been treated with the carcinogen dimethylhydrazine (DMH), vaccinated before DMH treatment with polyclonal IgG generated against the soluble 53 kDa protein, or left untreated. Emerging technologies to promote and evaluate physical activity: cutting-edge research and future directions. Few experiments have been carried out to evaluate the effects of toxic industrial substances such as the solvents on operant behavior. Electrophysiological characterization of voltage-dependent calcium currents and TRPV4 currents in human pulmonary fibroblasts. Examining glucose transport in single vascular smooth muscle cells with a fluorescent glucose analog.

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Renal disease is the major cause of morbidity and mortality in FLD cases, but an established therapy is not currently available. Adaptation to fragmentation: evolutionary dynamics driven by human influences. Hypoalgesia induced by counter-irritation is not affected by pCPA pretreatment.

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NAION secondary to APAC is a rare clinical entity that can result in severe vision loss. The authors estimated the incidence and predictors of difficult laryngoscopy in coronary artery bypass surgery patients. In this study we analyzed whether EVD, placed for acute hydrocephalus, is effective in reducing the incidence of clinical and radiological cerebral vasospasm in patients who underwent endovascular treatment for aneurysmal SAH. A simple method for the recovery of purified recombinant peptides cleaved from glutathione-S-transferase-fusion proteins.

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Health beliefs regarding selected problems were also obtained, along with non-orthodox practitioner (eg, chiropractors and naturopaths) utilization patterns. The aim was to study sequential changes of cardiac performance and structure after banding of ascending aorta. Thus, by screening for depression and other mood disorders in these critical periods, in addition to screening at routine intervals such as annual examinations, obstetricians and gynecologists can play an important role in early detection, prevention, and treatment of mood disorders and their comorbid conditions.

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Reduced microtubule acetylation in cystic fibrosis epithelial cells. Furthermore, the expression of apoptosis-related proteins was detected with Western blot in vitro and immunohistochemistry in vivo. The results showed that gamma-aminobutyric acid receptor gamma 1 subunit was expressed in the rat vestibule, indicating that GABA is one of the important neurotransmitters in the vestibular system.

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We used a Cox regression model with time-varying medication use and adjusted for stroke risk factors to estimate the hazard ratios (HRs) of ischemic stroke and intracranial hemorrhage associated with SNRI use, using SSRI use as a reference. Interdisciplinary neuro-oncology: part 1: diagnostics and operative therapy of primary brain tumors

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Genetic association study of P2x7 A1513C (rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies. Overseas studies have shown equivalent sensitivity and specificity between computer-assisted screening and manual screening, with increased screener productivity. Agricultural runoff pollution control by a grassed swales coupled with wetland detention ponds system: a case study in Taihu Basin, China.

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Exchondrosis of the pinna, a generally ignored posterior cartilaginous protuberance, may take on unusual clinical significance with regard to otoplasty. One of the key knowledge gaps concerns a refined understanding of the mechanisms that underlie arsenic mobilization, particularly under the onset of anaerobic conditions, and the quantification of the factors that affect this process. The prediction error rates of the optimized equations using the Breeder genetic algorithm are smaller than those provided by the multiple linear regression equations proposed in the recent study. The significance of early diagnosis in the therapeutical management of the patients is emphasized.

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In order to evaluate the effects of alcohol on appetite, 12 unrestrained and 10 restrained men ate lunch 20 min after consuming preloads consisting of water, an alcoholic fruit juice (alcohol) and a non-alcoholic fruit juice (juice). However, by lowering transmural urea concentration gradients, UTB reduces water efflux from DVR through aquaporin-1 (AQP1) water channels, thereby decreasing plasma sodium concentration. Electron-microscopy studies further demonstrated that cell bodies and processes of the DCs make close contact with lymphocytes. Squamous cell carcinoma is the second most common cutaneous malignancy after basal cell carcinoma. Design of PVP/VA S-630 based tadalafil solid dispersion to enhance the dissolution rate.

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Comparative study on perceived discrimination and subjective health status in two immigrants samples. This study investigated whether a typical (haloperidol, 0.035 mg/kg) and an atypical (clozapine, 2.5 mg/kg) antipsychotic could be distinguished in their ability to reverse PCP-induced deficits in PPI in eight monkeys ( Cebus apella). Vascular Rock and L-type Ca channel expression as well as Rock activation were investigated by quantitative real-time PCR and Western blot. The transmission and clinical consequences of hepatitis C viral (HCV) infection acquired by orthotopic heart transplantation (OHT) from an HCV-infected donor to an HCV-naive recipient have not been well described.

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Tumor-associated antigens in lung cancer tissues and in sera of tumor-bearing patients. All cases clinically diagnosed as Tay-Sachs disease at the American University Hospital, Beirut, during a period of 22 years (1957--1979) were reviewed. Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin co dalzad side effects and mucous membranes. In order to detect the proliferation of regenerative cells, labeling with BrdU and antibodies against phosphohistone H3 were employed.

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Functional electrical stimulation to ankle dorsiflexor and plantarflexor using single foot switch in patients with hemiplegia from hemorrhagic stroke. It was shown that differentiation and specialization of the smooth muscle cells is accomplished in the main features to the 3rd month of postnatal life. Buccal bone thickness at dental implants in the aesthetic zone: A 1-year staph epidermidis treatment bactrim f follow-up cone beam computed tomography study.

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Conversion of Jejunoileal Bypass to Silastic Ring Vertical Gastroplasty. Previous research has shown that 3-(dialkylamino)-5-phenylisoxazoles possessing a compact structure were active against HRV-2 and, consequently, presented a type B activity. This strain was identified by methods including 16S rDNA sequence homology and phylogenetic analysis morphological, biochemical and physiological characteristics analysis. The hormonal response used to compare the genotypes is the auxin-induced variation of the transplasmalemma electrical potential difference (delta Em) exhibited by protoplasts isolated from leaves amlodipine 5 mg side effects ukiah or root tips.

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