Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); multiple myeloma (a type of cancer of the bone marrow); and certain types of leukemia (cancer of the white blood cells), including chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML, ANLL), and acute lymphoblastic leukemia (ALL). It is also used to treat retinoblastoma (cancer in the eye), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and breast cancer. Cyclophosphamide is also used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications or in children who experienced intolerable side effects with other medications. Cyclophosphamide is in a class of medications called alkylating agents. When cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When cyclophosphamide is used to treat nephrotic syndrome, it works by suppressing your body's immune system.

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Synthesis of N-acetylglucosamine derivatives as probes for specificity of chicken hepatic lectin. Bactericidal Effect of Selected Antidiarrhoeal Medicinal Plants on Intracellular Heat-Stable Enterotoxin-Producing Escherichia coli. Cytotoxicity assessment of three therapeutic agents, cyclosporin-A, cisplatin and doxorubicin, with the ciliated protozoan Tetrahymena pyriformis. Three-dimensional (3-D) ultrasound is a widely available, low-cost imaging modality that may be used to provide real-time feedback to needle steering robots.

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LAMP is an isothermal amplification method that can achieve ultra-high sensitivity and specificity. Selective use of image-guided thermal ablation of oligometastatic melanoma may provide results similar to surgical resection in terms of technical effectiveness and oncologic outcomes with minimal risk. Currently, thoracentesis and cytologic analysis of pleural fluid cytology is usually the initial diagnostic step. The use of stable isotope tags in quantitative peptidomics offers many advantages, but the laborious identification of matching sets of labeled peptide peaks is still a major bottleneck. Moreover, using a replication defective ras1 knockout strain of Cryptococcus increased degranulation occurred during more rapid replication of the organisms.

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These results suggest that NOACs as the first choice oral anticoagulant in AF patients with renal dysfunction. Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction.

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Each population of fleas has a corresponding autonomic plague focus. BALB/c mice were immunised intramuscularly with plasmid DNA and serum antibody responses measured by enzyme linked immunosorbant assay (ELISA). On the relationship between time-series studies, dynamic population studies, and estimating loss of life due to short-term exposure to environmental risks. While performance was not improved by the use of expression-specific diagnostic facial features, performance increased with presentation time for all emotions. Enlarged mesenteric lymph nodes were seen in the pig inoculated with PCV2 alone and killed at 26 days post-inoculation (PI).

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Additional missense mutations were introduced into the mal61/HA-581NS allele, altering potential phosphorylation and ubiquitination sites. Cyclopropyl carbocyclic nucleosides have been synthesized from the key intermediate 2 which was converted to the mesylated cyclopropyl methyl alcohol 3. Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein. ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope. We retrospectively reviewed the results of right anterolateral thoracotomy compared with conventional median sternotomy (CMS) for ASD closure at Seoul National University Hospital.

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Of 110 T1-2N1 breast cancer patients who underwent mastectomy from January 1994 through December 2009, 32 patients underwent PMRT and 78 patients did not. Behavioral and c-fos expression changes induced by nitric oxide donors microinjected into the dorsal periaqueductal gray. We examined expression and cytotoxic triggering capability of the three Fc receptors for IgG (Fc gamma R) on human monocytes, PMNs and myeloid cell lines after in vitro culture with various cytokines. High levels of plasma total homocysteine (tHcy) are involved in arterial or venous occlusive diseases.

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Atrial fibrillation (AF) is the most common sustained arrhythmia in adults and is associated with an increased risk of fatal and non-fatal events. Effect of NaX zeolite-modified graphite felts on hexavalent chromium removal in biocathode microbial fuel cells. ZER-mediated cleavage of Notch2 protein in MDA-MB-231 cells was markedly attenuated upon RNA interference of Presenilin-1. Plasma Se concentration and RBC GSH-Pxs activity were measured in each patient at the beginning and at the end of the study. Use of crown ethers to isolate intermediates in ammonia-borane dehydrocoupling reactions.

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The correlation between domains structure of the fibrinogen molecule and the exon/intron composition of the genes encoding the three fibrinogen polypeptide chains has been analysed. Here, we used directed hydroxyl radical probing from four unique positions on S15 to assess organization of the central domain of 16S rRNA as a consequence of S8 association.

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Methylmercury (MeHg) is an environmental electrophile that covalently modifies cellular proteins with reactive thiols, resulting in the formation of protein adducts. In vitro amplification using the polymerase chain reaction followed by oligonucleotide hybridization can be used to detect murine CMV DNA. Validation of clinical predictive value of in vitro colorimetric chemosensitivity assay in head and neck cancer. Further improvement of blood pressure control may be achievable by use of a larger dose of enalaprilat or a 4-hr enalaprilat-dosing interval. The density of prestin protein expression of the basal turn was not significantly different after exposure to the different doses of radiation compared with the control group, but up-regulation occurred after radiation in the apex turn.

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MCC is a cutaneous neuroendocrine malignant tumor arising from Merkel cells. Attention and written expression in school-age, high-functioning children with autism spectrum disorders. In tree-based taxonomy assignment approach, reliable identification of anonymous OTUs is based on their placement in monophyletic and highly supported clades together with identified reference taxa. Nowadays,most of the pathogenic bacteria become resistant to antibiotics.

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A study protocol for performance evaluation of a new academic intensive care unit facility: impact on patient care. Entrapment of the left anterior descending coronary artery by localized calcific pericarditis: from dynamic to fixed coronary stenosis.

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Triclosan-coated sutures are often used to reduce the risk of SSI, but studies examining this have given conflicting results. We think that this method had advantages over deep hypothermic circulatory arrest with regard to intraoperative risks and postoperative complications.

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The proposed prediction procedure also accounts for the mechanism of action introduced by cancer immunotherapies, such as delayed and long-term survival effects. In BDV infection, however, cytoplasmic distribution of the viral proteins is frequently found in cultured cells and animal brains. Furthermore, we found that the level of government political commitment through primary health care and in the provision of essential medicines was an important factor in promoting access to medications.

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Evaluation of extracts and essential oil from Callistemon viminalis leaves: antibacterial and antioxidant activities, total phenolic and flavonoid contents. Effects of vasopressin on insulin secretion and inositol phosphate production in a hamster beta cell line (HIT). The anorectic gut hormone, peptide YY (PYY), is released from colonic mucosal endocrine cells, but little is known about the role for tachykinin NK3 receptor in the control of PYY release from the colonic mucosa. Cox proportional hazards models and subgroup analyses were used to estimate the association of unfinished RCTs on the risk of pneumonia hospitalization.

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The clinical manifestation and initial lesion on brain DWI mimicked top of basilar syndrome, but without an arterial occlusion or stenosis. Activation of rat recombinant alpha(1)beta(2)gamma(2S) GABA(A) receptor by the insecticide ivermectin. Therefore, we conducted a second similar experiment using water as the reward. For some patients with recurrent, unresectable, and previously irradiated head and neck squamous cell carcinoma (HNSCC), reirradiation (re-RT) may be a curative option. Ophthalmologic evaluation of VDT/PC operators: approach to the diagnosis with neural networks

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Z scores were calculated for cognitive tests, and then grouped into domains of executive function (EF), psychomotor processing speed (PS), and memory. The Semmes-Weinstein monofilament, moving and static 2-point discrimination, roughness differentiation, stereognosis and barognosis subtests of the MTT, and precision pinch performance were used to examine the sensory and sensorimotor status of the hand. Health-related quality of life in patients with melanoma expressed as utilities and disability weights. Three of the eight patients required omission of TMZ for part of their chemoradiotherapy and 3/8 required hospital admission at some point during chemoradiotherapy. The role of oxidants in mitochondrial dysfunction was further confirmed by the use of iNOS inhibitors or antioxidants that preserve cytochrome c oxidase activity and prevent mitochondrial membrane potential dissipation.

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Two of the 4 subjects were first trained and tested using the ZC scheme while the other 2 used the FB scheme. Although the percentage of gene-marked cells was high and remained stable in NOD/SCID mice up to 12 weeks and in those that underwent secondary transplantation, we observed a considerable decline and overall a significantly (10-fold) lower percentage of gene-marked cells in the baboons. Our objective was to assess their vaccine risk perception and thereby to identify strategies to prevent further deterioration in uptake.

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Thus, understanding the regulation of LOX expression may be of crucial importance for elucidation of the process of rupture of the fetal membranes. Identification and characterization of LDL receptor gene mutations in hyperlipidemic Chinese. Modeling Flow Coating of Colloidal Dispersions in the Evaporative Regime: Prediction of Deposit Thickness. We have previously shown that autophosphorylation of CaMKII induces high-affinity binding to the NR2B subunit of the NMDA receptor (Strack, S., and Colbran, R.

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Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. However, the precise mechanisms underlying its effects are unknown. Karl Alfons Portele, Pathologist and first director of the Federal Pathologic-anatomical Museum Vienna Participants also completed a short survey describing their perceptions of the AR technology.

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The wave vector matching between the propagating wave and the spoof SPPs has been achieved at several frequencies for certain wave vector provided by the metasurface, which leads to wideband spoof SPPs coupling. Resection of carcinoma of the gastroesophageal junction was followed by the development of a penetrating ulcer at the anastomosis site with perforation into the left atrium. Not only was ASV ineffective but post hoc analysis found excess cardiovascular mortality in treated patients. Lupus anticoagulants have been recognized as significant causes of morbidity in patients for many years.

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The best results in loosing body weight, especially body fat use very low calorie diets followed by a fat-reduced, carbohydrate-rich diets. The high affinity and slow overall kinetics of association and dissociation of alphaII-betaII spectrin may suit it well to a role in strengthening cell junctions and providing stable anchor points for transmembrane proteins at points specified by cell-adhesion molecules.

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A promising reconditioning strategy is the administration of inhaled noble gases based on their organoprotective effects. Treatment with NAC reduced the endothelial leakage of albumin in the ileum, colon and lungs, whereas administration of the PAF inhibitor alone demonstrated a protective effect only in the ileum.

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The Delphi questionnaire will be administered via SurveyMonkey and conducted using standard Delphi Methodology. In hamsters treated with dihydroxy-di-n-propylnitrosamine (DHPN) for induction of pancreatic duct carcinomas, the early duct lesions closely resembled atypical epithelial proliferation of human pancreas. The relational memory impairment persisted at follow-up and correlated with symptom severity both at baseline and follow-up. Independent projection streams from macaque striate cortex to the second visual area and middle temporal area. This study provides unequivocal proof that the A ring of EGCG and EGC may also be an antioxidant site.

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The effect of rivastigmine on sleep in elderly healthy subjects. A comparison of human tumour-cell clonogenicity in methylcellulose and agar culture. In group 1C we found the most vital flap tissue, without reaching significance.

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Treatment of skeletal muscle myosin yielded a 97-kDa split heavy chain associated with intact light chains, corresponding to a single cut. Data were collected using a purposive sampling method from 100 nursing students using a self-reported questionnaire composed of Perceived Stress Scale and Coping Behavior Inventory.

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Clinical efficacy and safety of the orally inhaled neuraminidase inhibitor zanamivir in the treatment of influenza: a randomized, double-blind, placebo-controlled European study. In patients with preoperative LV mass exceeding 250 g/m2, ejection fraction failed to return to normal postoperatively, despite reduction in ESS close to the normal controls. Knowledge of those cytokines or a better understanding of the proliferative responses is pivotal in evaluation of FPV vaccines and in the design of FPV-based recombinant vaccines. Microarray gene expression analysis identified genes activated during erythroid maturation, and NIC-1 disrupted the maturation-dependent changes in the expression of these genes. The amplitude and latency of the N170 component were recorded while participants passively viewed face and non-face (table) images to explore the correlation between face-specific processing and clinical characteristics in schizophrenia.

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Traumatic brain injury (TBI) presents with a secondary cell death characterized by neuroinflammation that is putatively regulated by nuclear receptors. Error modelling in anaesthesia: slices of Swiss cheese or shavings of Parmesan.

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Findings suggest that elevated exposures to the feto-placental stress signal pCRH exert programming effects on the developing fetal central nervous system, with lasting consequences for child mental health. Three patients were treated using the same technique with a mean interval between the index procedure and reintervention of 9.3 months (range, 3-15 mo). The samples were analysed using cation- and anion-exchange HPLC-HG-AFS for speciation and ICP-AES for the total As determination. We report the use of intrathecal treatment with methotrexate and methylprednisolone in three children (one male, two females, age 10y, 11y, and 14y) with anti-NMDAR encephalitis, who did not respond to steroids, plasmapheresis, or rituximab.

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The European study on the natural history of HIV infection in women is a prospective cohort study of 487 HIV-infected women with a known interval of seroconversion from 12 European countries. Therapeutic experiences with a new sulfonamide mixture, dosulfin This study aimed at evaluating the effect of omeprazole on bone in normal and ovariectomized Wistar rats and the possible mechanisms involved. This study used a Halimeter to investigate fixed orthodontic therapy-associated increases in the oral malodor over a year.

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Synthetic Method for Oligonucleotide Block by Using Alkyl-Chain-Soluble Support. These results suggested a role of brain-derived neurotrophic factor in the physiological regulation of tactile sense in adulthood.

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Alternating flooding and drainage conditions have a strong influence on redox chemistry and the solubility of trace metals in paddy soils. Anesthetic side effects and complications: seeking, finding, and treating. Impact of soil heat on reassembly of bacterial communities in the rhizosphere microbiome and plant disease suppression. The Use of the Sternocleidomastoid Flap Helps Reduce Complications After Free Jejunal Flap Reconstructions in Total Laryngectomy and Cervical Esophagectomy Defects. Peripheral blood neutrophils were isolated from healthy volunteers and tested in vitro with first trimester trophoblast cell line (Swan-71 and HTR8) conditioned media (CM) or with VIP.

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Two review authors independently assessed study reports for eligibility, carried out data extraction and assessed risk of bias. We have found this to be a simple and effective means of insuring good follow-up care of our head and neck tumor patients and for providing an index for retrieving charts to review a series of cases with a specific type of tumor. All 4 genetic metrics selected approximately similar conservation-priority areas, which is likely a result of prioritizing genetic patterns across a genetically diverse array of species. Arabidopsis thaliana maintains a complex metabolism for the production of secondary or specialized metabolites.

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As with any therapeutic intervention, in the evaluation of medical treatment of chronic cardiac failure, methods of assessing the efficacy of the drug (for example, measuring haemodynamic parameters) have to be distinguished from those designed to show therapeutic benefit (for example, prolongation of survival, quantified improvement in performance without excess mortality or deterioration in the quality of life). The scoliosis of our patient with Wiedemann-Rautenstrauch syndrome showed radiologically and clinically the characteristics of a neuromuscular curve.